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HRID1168664

反应详情

EQUATION

反应方程式

HRID 1168664 的结构方程式

REACTANTS

反应物

3
结构：II
HCID807

Iodine

I2

结构：CN(C)CCN
HCID66053

N,N-Dimethylethylenediamine

C4H12N2

结构：CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC(=O)Cl)CC[C@]4(C)[C@H]3CC[C@]12C
HCID111262

3-Cholesteryl chloroformate

C28H45ClO2

PRODUCTS

生成物

1
结构：CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](OC(=O)NCCN(C)C)CC[C@]4(C)[C@H]3CC[C@]12C
HCID115234

Cholest-5-en-3-yl hydrogen [2-(dimethylamino)ethyl]carbonimidate

C32H56N2O2

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClC(Cl)Cl
溶剂HCID6212

Chloroform

CHCl3

2 次

PROCEDURE

实验过程

Compound XIV was synthesized by mixing a-solution of cholesterol chloroformate (0.5 mmol) in chloroform with a solution of N,N-dimethylethylenediamine (9.1 mmol) in chloroform in a dry ice-ethanol bath. The solvent and the unreacted amine were removed in vacuo. Compound XIV was purified by two successive recrystallizations in ethanol. (Yield, 65%) TLC (chloroform:methanol=65:35) showed a single spot (Rf=0.37) when developed with iodine. The product was characterized by proton NMR.

WORKUP

后处理

  1. customThe solvent and the unreacted amine were removed in vacuo
  2. customCompound XIV was purified by two successive recrystallizations in ethanol
  3. custom(Yield, 65%) TLC (chloroform:methanol=65:35)