Methyl morpholine oxide → HCID 22989453, compound

HRID 1168696Notes

Reaction equation

HRID 1168696 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][C:14]([CH2:20][CH2:21][OH:22])([CH2:17][CH2:18][OH:19])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[N+]1([O-])CCOCC1>C(Cl)Cl.C(#N)C.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][C:14]2([CH2:17][C:18](=[O:19])[O:22][CH2:21][CH2:20]2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 82029Methyl morpholine oxideHCID 22989502Phenylmethyl 4,4-bis(2-hydroxyethyl)-1-piperidinecarboxylate

Product 1

HCID 22989453HCID 22989453, compound

Reagents, catalysts & solvents 2

HCID 178419074HCID 178419074, compoundCatalystHCID 21877088Acetonitrile methylene chlorideSolvent

Procedure

9-benzyloxycarbonyl-2-oxo-3-oxa-9-azaspiro[5.5]undecane is prepared by reaction of 1-benzyloxycarbonyl-4,4-bis-(2-hydroxyethyl)piperidine with 4-methylmorpholine-N-oxide in methylene chloride/acetonitrile in the presence of tetrapropylammonium perruthenate and pulverized molecular sieve.

Sources & evidence

ORD record
ord-7af92ea1f6f04092802fdd124e22f966
Source dataset
uspto-grants-2003_09
Patent number
US06627634B2

Reaction notes

Loading…