反应详情

温度

90 °C

A mixture of glycine tert-butyl ester hydrochloride (3.35 g, 20 mmol), 4-nitrofluorobenzene (2.82 g, 20 mmol) and potassium carbonate (4.2 g, 30 mmol) in DMSO (15 mL) was heated at 90° C. for 22 hr. The reaction mixture was allowed to cool to room temperature and then poured onto crushed ice. The precipitated yellow solid was filtered, washed with water and dried (Na2SO4) to give N-(4-nitrophenyl)glycine tert-butyl ester (4.1 g, 81%).

1. temperatureto cool to room temperature
2. additionpoured
3. customonto crushed ice
4. filtrationThe precipitated yellow solid was filtered
5. washwashed with water
6. dry with materialdried (Na2SO4)