3-Amino-1-propanol → HCID 11769376, compound

HRID 1169024Notes

Reaction equation

HRID 1169024 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:8]=[CH:9][N:10]=2)[N:7]=1.[NH2:11][CH2:12][CH2:13][CH2:14][OH:15]>C(O)C>[OH:15][CH2:14][CH2:13][CH2:12][NH:11][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:8]=[CH:9][N:10]=2)[N:7]=1

Participants

4

Reactant 2

HCID 90863-Amino-1-propanolHCID 112406116-Chloro-(1,2,4)triazolo(1,5-b)pyridazine

Product 1

HCID 11769376HCID 11769376, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

6-Chloro[1,2,4]triazolo[1,5-b]pyridazine (928 mg) was dissolved in ethanol (10 ml). 3-Amino-1-propanol (1.23 g) was added to the solution. The mixture was refluxed under heating for 20 hours. After being cooled, the mixture was concentrated under reduced pressure to an half of its volume. The resulting precipitates were washed with ethanol and dried to yield the title compound (835 mg).

Workup

  1. temperatureThe mixture was refluxed
  2. temperatureunder heating for 20 hours
  3. temperatureAfter being cooled
  4. concentrationthe mixture was concentrated under reduced pressure to an half of its volume
  5. customThe resulting precipitates
  6. washwere washed with ethanol
  7. customdried

Sources & evidence

ORD record
ord-1ff5f117217b42bf9cb6f8c556e5df79
Source dataset
uspto-grants-2003_09
Patent number
US06627630B1

Reaction notes

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