Sodium Hydroxide → HCID 11746720, compound

HRID 1169121Notes

Reaction equation

HRID 1169121 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([CH3:17])([CH3:16])[C:12]([O:14]C)=[O:13])[N:10]=2)[N:7]=1.[OH-].[Na+]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([CH3:17])([CH3:16])[C:12]([OH:14])=[O:13])[N:10]=2)[N:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11075988HCID 11075988, compound

Product 1

HCID 11746720HCID 11746720, compoundYield 80.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.40 g of methyl 2-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-2-methylpropionate was dissolved in 15 ml of tetrahydrofuran; 9 ml of a 1 N aqueous solution of sodium hydroxide was added, followed by stirring at room temperature for 3 hours. After the mixture was concentrated under reduced pressure. The residue was adjusted top H4 by the addition of 1N hydrochloric acid; the crystal precipitated was collected by filtration to yield 1.06 g of the title compound.

Workup

  1. concentrationAfter the mixture was concentrated under reduced pressure
  2. additionby the addition of 1N hydrochloric acid
  3. customthe crystal precipitated
  4. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-85b1d20b86504078a24ddfa853caf36d
Source dataset
uspto-grants-2003_09
Patent number
US06627630B1

Reaction notes

Loading…