HCID 10122634, compound → HCID 10283374, compound

HRID 1169293Notes

Reaction equation

HRID 1169293 reaction equation
[CH2:1]([N:8]([C:47](=[O:51])[C:48]([OH:50])=[O:49])[CH2:9][CH:10]([CH:41]1[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]1)[C:11]1[CH:16]=[CH:15][C:14](/[CH:17]=[CH:18]/[C:19]([NH:21][C:22]2[CH:27]=[C:26]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[C:25]([OH:34])=[C:24]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[CH:23]=2)=[O:20])=[CH:13][CH:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C.[Pd]>[CH2:1]([N:8]([C:47](=[O:51])[C:48]([OH:50])=[O:49])[CH2:9][CH:10]([CH:41]1[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]1)[C:11]1[CH:12]=[CH:13][C:14]([CH2:17][CH2:18][C:19]([NH:21][C:22]2[CH:23]=[C:24]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[C:25]([OH:34])=[C:26]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH:27]=2)=[O:20])=[CH:15][CH:16]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 10122634HCID 10122634, compound

Product 1

HCID 10283374HCID 10283374, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of Example 39 (34.0 mg, 0.050 mmol) and 10% Pd/C (5.0 mg) in ethanol (2.0 mL) at room temperature was stirred under hydrogen for 16 hours, filtered through diatomaceous earth (Celite®) with ethanol rinsing, and concentrated to provide the desired product.

Workup

  1. filtrationfiltered through diatomaceous earth (Celite®) with ethanol rinsing
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-38c49f9be7494d51a5ede70670b8290d
Source dataset
uspto-grants-2003_09
Patent number
US06627767B2

Reaction notes

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