反应详情

A solution of ethyl (Z)-2-azido-3-(4-bromophenyl)acrylate (6.24 g) in xylene (200 ml) was heated at reflux for 4 hours. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure, and the precipitated crystals were collected by filtration. The crystals were washed with xylene and hexane to obtain ethyl 6-bromo-1H-indole-2-carboxylate (3.21 g) as colorless crystals.

1. temperatureat reflux for 4 hours
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. filtrationthe precipitated crystals were collected by filtration
4. washThe crystals were washed with xylene and hexane