反应详情

To N-[1-(t-butoxycarbonyl)piperidin-4-yl]-7-(4-methylphenyl)-2,3-dihydro-1-benzooxepine-4-carboxamide (1.56 g) dissolved in ethyl acetate (100 ml) was added 4 N hydrochloric acid/ethyl acetate (25 ml), and the resulting mixture was stirred at room temperature overnight. The reaction mixture was mixed with a 1 N aqueous solution of sodium hydroxide and was extracted with ethyl acetate. The organic layer was washed with water and an aqueous saturated solution of sodium chloride, and then was dried with anhydrous magnesium sulfate. The resulting organic layer was evaporated under reduced pressure to remove the solvent to obtain N-(4-piperidinyl)-7-(4-methylphenyl)-2,3-dihydro-1-benzooxepine-4-carboxamide (compound 54) (1.1 g) as colorless prisms.

1. extractionwas extracted with ethyl acetate
2. washThe organic layer was washed with water
3. dry with materialan aqueous saturated solution of sodium chloride, and then was dried with anhydrous magnesium sulfate
4. customThe resulting organic layer was evaporated under reduced pressure
5. customto remove the solvent