反应详情

To benzyl trans-4-(tert-butoxycarbonylaminomethyl)cyclohexylcarbamate (18.93 g) was added concentrated hydrochloric acid (60 ml), and the resulting mixture was stirred at room temperature for 16 hours. The reaction mixture was mixed with ethanol and was then concentrated under reduced pressure. The residue was mixed with diethyl ether, and the precipitated crystals were collected by filtration. The crystals were washed with diethyl ether to obtain benzyl trans-4-aminomethylcyclohexylcarbamate hydrochloride (11.76 g) as colorless crystals.

1. concentrationwas then concentrated under reduced pressure
2. additionThe residue was mixed with diethyl ether
3. filtrationthe precipitated crystals were collected by filtration
4. washThe crystals were washed with diethyl ether