Hydrochloric Acid → HCID 178479229, compound

HRID 1169410Notes

Reaction equation

HRID 1169410 reaction equation
C(OC([NH:8][CH2:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([NH:16][C:17](=[O:26])[O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:12][CH2:11]1)=O)(C)(C)C.[ClH:27]>C(O)C>[ClH:27].[NH2:8][CH2:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([NH:16][C:17](=[O:26])[O:18][CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178453647HCID 178453647, compound

Product 1

HCID 178479229HCID 178479229, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To benzyl trans-4-(tert-butoxycarbonylaminomethyl)cyclohexylcarbamate (18.93 g) was added concentrated hydrochloric acid (60 ml), and the resulting mixture was stirred at room temperature for 16 hours. The reaction mixture was mixed with ethanol and was then concentrated under reduced pressure. The residue was mixed with diethyl ether, and the precipitated crystals were collected by filtration. The crystals were washed with diethyl ether to obtain benzyl trans-4-aminomethylcyclohexylcarbamate hydrochloride (11.76 g) as colorless crystals.

Workup

  1. concentrationwas then concentrated under reduced pressure
  2. additionThe residue was mixed with diethyl ether
  3. filtrationthe precipitated crystals were collected by filtration
  4. washThe crystals were washed with diethyl ether

Sources & evidence

ORD record
ord-f7562749754244398fd18f466c326a25
Source dataset
uspto-grants-2003_09
Patent number
US06627651B1

Reaction notes

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