Sodium borohydride → HCID 86628156, compound

HRID 1169552Notes

Reaction equation

HRID 1169552 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([F:10])([F:9])[F:8])[C:4]([CH2:11][C:12]#[N:13])=[N:3]1.[C:14](=O)([O:20]C(C)(C)C)[O:15][C:16]([CH3:19])([CH3:18])[CH3:17].[BH4-].[Na+]>O.O.O.O.O.O.[Ni](Cl)Cl.CO>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([F:8])([F:9])[F:10])[C:4]([CH2:11][CH2:12][NH:13][C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[N:3]1

Participants

6

Reactant 3

HCID 4311764Sodium borohydrideHCID 10219638Carbonic acid, bis(1,1-dimethylethyl) esterHCID 68766582HCID 68766582, compound

Product 1

HCID 86628156HCID 86628156, compound

Reagents, catalysts & solvents 2

HCID 11791229Dichloronickel;hexahydrateCatalystHCID 887MethanolSolvent

Procedure

The [1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl]acetonitrile (4.76 mmol, 0.90 g), the di-terbutyl carbonate (9.52 mmol, 2.08 g) and nickel chloride hexahydrate (4.77 mmol, 1.13 g) are added to methanol (10 ml) at room temperature. Sodium borohydride (13.1 mmol, 0.49 g). is added portionwise to the reaction mixture. The reaction mixture is allowed to room temperature and stirred for three hours.

Workup

  1. additionis added portionwise to the reaction mixture
  2. customis allowed to room temperature

Sources & evidence

ORD record
ord-50dd3d71a89d450f9f61cd0575efbd01
Source dataset
uspto-grants-2010_11
Patent number
US07825068B2

Reaction notes

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