反应详情

The procedure of synthesizing Compound 34a was repeated, except that 2-methylpentan-2-ylmagnesium chloride THF solution (100 mL), which had been prepared from magnesium (2.43 g, 100 mmol) and 2-chloro-2-methylpentane (12.0 g, 99.0 mmol); trichlorosilane (9.70 mL, 96.1 mmol); and ethylmagnesium chloride THF solution (0.93M, 200 mL, 1.86 mmol) were employed, whereby the Compound 42a was obtained as a colorless liquid (boiling point; 40 mmHg, 100 to 103° C. fraction, 6.62 g, 40%).