Hydrochloric Acid → HCID 67237571, compound

HRID 1169588Notes

Reaction equation

HRID 1169588 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:18]3[CH:19]=[N:20][CH:21]=[CH:22][C:17]=3[O:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23].O1CCOCC1>C(Cl)Cl>[ClH:23].[ClH:23].[N:11]1([C:14]2[C:18]3[CH:19]=[N:20][CH:21]=[CH:22][C:17]=3[O:16][N:15]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59252268HCID 59252268, compound

Product 1

HCID 67237571HCID 67237571, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-Isoxazolo[4,5-c]pyridin-3-yl-piperazine-1-carboxylic acid tert-butyl ester (960 mg, 3.1 mmol) was dissolved in CH2Cl2 (2 ml) and 4 N HCl in dioxane (15.7 ml, 63 mmol) was added. The resulting mixture was stirred 16 h at r.t. After dilution with iPr2O the product was collected by filtration and washed with one portion of iPr2O before drying it under high vacuum at 50° C. to obtain 850 mg (97%) as a pink solid. m/z=205.2 ([M+H]+).

Workup

  1. filtrationAfter dilution with iPr2O the product was collected by filtration
  2. washwashed with one portion of iPr2O
  3. custombefore drying it under high vacuum at 50° C.
  4. customto obtain 850 mg (97%) as a pink solid

Sources & evidence

ORD record
ord-44572ec6024d4706b31180863e468c20
Source dataset
uspto-grants-2010_11
Patent number
US07825123B2

Reaction notes

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