Hydrochloric Acid → HCID 178478719, compound

HRID 1169590Notes

Reaction equation

HRID 1169590 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][N:19]([C:22]3[C:26]4[CH:27]=[N:28][CH:29]=[CH:30][C:25]=4[O:24][N:23]=3)[CH2:18][CH2:17]2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:32].O1CCOCC1>C(Cl)Cl>[ClH:32].[ClH:32].[O:24]1[C:25]2[CH:30]=[CH:29][N:28]=[CH:27][C:26]=2[C:22]([N:19]2[CH2:18][CH2:17][N:16]([CH2:15][CH2:14][C@H:11]3[CH2:12][CH2:13][C@H:8]([NH2:7])[CH2:9][CH2:10]3)[CH2:21][CH2:20]2)=[N:23]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 178453915HCID 178453915, compound

Product 1

HCID 178478719HCID 178478719, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

{trans-4-[2-(4-Isoxazolo[4,5-c]pyridin-3-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-carbamic acid tert-butyl ester (930 mg, 2.2 mmol) was dissolved in CH2Cl2 (3 ml) and 4 N HCl in dioxane (10.8 ml, 43 mmol) was added. The resulting mixture was stirred 16 h at r.t. After dilution with iPr2O the product was collected by filtration and washed with one portion of iPr2O before drying it under high vacuum at 50° C. to obtain 686 mg (79%) as a white solid. m/z=330.3 ([M+H]+).

Workup

  1. filtrationAfter dilution with iPr2O the product was collected by filtration
  2. washwashed with one portion of iPr2O
  3. custombefore drying it under high vacuum at 50° C.
  4. customto obtain 686 mg (79%) as a white solid

Sources & evidence

ORD record
ord-d30fbe2da0e64b85a81f62b3bb31ba9f
Source dataset
uspto-grants-2010_11
Patent number
US07825123B2

Reaction notes

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