5-Iodosalicylic acid → Tert-butyl 4-(2-hydroxy-5-iodobenzoyl)piperazine-1-carboxylate

HRID 1169596Notes

Reaction equation

HRID 1169596 reaction equation
ClC1C=CC(C([N:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]2)=O)=CC=1C#N.[OH:25][C:26]1[CH:34]=[CH:33][C:32]([I:35])=[CH:31][C:27]=1[C:28]([OH:30])=O>>[OH:25][C:26]1[CH:34]=[CH:33][C:32]([I:35])=[CH:31][C:27]=1[C:28]([N:8]1[CH2:9][CH2:10][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:12][CH2:13]1)=[O:30]

Participants

3

Reactant 2

HCID 83885-Iodosalicylic acidHCID 68766029Tert-butyl 4-(4-chloro-3-cyanobenzoyl)piperazine-1-carboxylate

Product 1

HCID 31121968Tert-butyl 4-(2-hydroxy-5-iodobenzoyl)piperazine-1-carboxylate

Procedure

Performed identical to tert-butyl 4-(4-chloro-3-cyanobenzoyl)piperazine-1-carboxylate in Example 1 except 2-hydroxy-5-iodobenzoic acid was used in place of 3-cyano-4-chlorobenzoic acid.

Sources & evidence

ORD record
ord-d0384ed933044b5ca5f5f86bcfb212fd
Source dataset
uspto-grants-2010_11
Patent number
US07825120B2

Reaction notes

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