HCID 68766655, compound → HCID 68765121, compound

HRID 1169604Notes

Reaction equation

HRID 1169604 reaction equation
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[C@H:12]([C:14]1[CH:15]=[C:16]([CH:31]=[CH:32][CH:33]=1)[CH2:17][N:18]1[CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:20][CH2:19]1)[CH3:13]>NN>[NH2:3][C@H:12]([C:14]1[CH:15]=[C:16]([CH:31]=[CH:32][CH:33]=1)[CH2:17][N:18]1[CH2:19][CH2:20][N:21]([C:24]([O:26][C:27]([CH3:28])([CH3:30])[CH3:29])=[O:25])[CH2:22][CH2:23]1)[CH3:13]

Participants

3

Reactant 1

HCID 68766655HCID 68766655, compound

Product 1

HCID 68765121HCID 68765121, compound

Reagents, catalysts & solvents 1

HCID 9321HydrazineSolvent

Procedure

The (S)-tert-butyl 4-(3-(1-(1,3-dioxoisoindolin-2-yl)ethyl)benzyl)piperazine-1-carboxylate from the previous step (490 mg, 1.09 mmol) was dissolved in 5 mL hydrazine and stirred at ambient temperature for 16 h. The solvent was removed at reduced pressure and the resulting (S)-tert-butyl 4-(3-(1-aminoethyl)benzyl)piperazine-1-carboxylate was used in the next step without additional purification.

Workup

  1. customThe solvent was removed at reduced pressure
  2. customthe resulting (S)-tert-butyl 4-(3-(1-aminoethyl)benzyl)piperazine-1-carboxylate was used in the next step without additional purification

Sources & evidence

ORD record
ord-3114bba512b94dd2812849480bcdc7fa
Source dataset
uspto-grants-2010_11
Patent number
US07825120B2

Reaction notes

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