Methyl iodide → HCID 18770853, compound

HRID 1169609Notes

Reaction equation

HRID 1169609 reaction equation
[Br:1][C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[CH:5]=[C:4]([OH:12])[CH:3]=1.[C:13]([O-])([O-])=O.[K+].[K+].CI>CC(C)=O>[Br:1][C:2]1[CH:3]=[C:4]([O:12][CH3:13])[CH:5]=[C:6]2[C:11]=1[CH2:10][CH2:9][CH2:8][CH2:7]2

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 18770850HCID 18770850, compound

Product 1

HCID 18770853HCID 18770853, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

5,6,7,8-tetrahydro-4-bromo-2-naphthol (7 g, 30.8 mmol; step c) in example 29) is dissolved in dry acetone (100 ml) and treated with K2CO3 (15 g, 0.11 mol) and methyliodide (7.25 ml, 0.13 mmol). The reaction mixture is kept at RT over night. After filtration and removal of the solvent the residue is purified over silica gel (methylene chloride/cyclohexane 1/1) affording the compound as a white solid.

Workup

  1. waitThe reaction mixture is kept at RT over night
  2. filtrationAfter filtration and removal of the solvent the residue
  3. customis purified over silica gel (methylene chloride/cyclohexane 1/1)

Sources & evidence

ORD record
ord-7c9e1bc9bd674be28405d01b4fb466b5
Source dataset
uspto-grants-2010_11
Patent number
US07825124B2

Reaction notes

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