反应详情

1.16 ml of triethylamine and 0.64 ml of methanesulfonyl chloride are successively added to a solution of 1.2 g of 4-hydroxymethyl-6-methoxyquinoline in 45 ml of dichloromethane, under an inert atmosphere of argon at a temperature in the region of 20° C. Stirring is maintained at this temperature for 3 hours. The reaction medium is concentrated under reduced pressure to give a brown residue. The product is used without further purification in the following step.

1. temperatureis maintained at this temperature for 3 hours
2. concentrationThe reaction medium is concentrated under reduced pressure
3. customto give a brown residue
4. customThe product is used without further purification in the following step