1H-Imidazole-1-propanamine → 3(2-Chloro-5-thiophen-2-yl-pyrimidine-4-yl)-(3-imidazol-1-yl-propyl)-amine

HRID 1169741Notes

Reaction equation

HRID 1169741 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5](I)=[CH:4][N:3]=1.[N:10]1([CH2:15][CH2:16][CH2:17][NH2:18])[CH:14]=[CH:13][N:12]=[CH:11]1.CC1(C)C(C)(C)OB([C:27]2[S:28][CH:29]=[CH:30][CH:31]=2)O1>>[Cl:1][C:2]1[N:7]=[C:6]([CH:15]([N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)[CH2:16][CH2:17][NH2:18])[C:5]([C:27]2[S:28][CH:29]=[CH:30][CH:31]=2)=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 787361H-Imidazole-1-propanamineHCID 2634382,4-Dichloro-5-iodopyrimidineHCID 107036284,4,5,5-Tetramethyl-2-(thiophen-2-yl)-1,3,2-dioxaborolane

Product 1

HCID 866154793(2-Chloro-5-thiophen-2-yl-pyrimidine-4-yl)-(3-imidazol-1-yl-propyl)-amine

Procedure

Preparation according to procedures 2 and 3 with the use of 2,4-dichloro-5-iodo-pyrimidine, 3-imidazol-1-yl-propylamine and 4,4,5,5-tetramethyl-2-(2-thienyl)-1,3,2-dioxaborolane.

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-22736563edbc4b00aee5897ed2a605ea
Source dataset
uspto-grants-2010_11
Patent number
US07825128B2

Reaction notes

Loading…