4,4,5,5-Tetramethyl-2-(thiophen-2-yl)-1,3,2-dioxaborolane → 2-Chloro-4-methoxy-5-thiophen-2-yl-pyrimidine

HRID 1169745Notes

Reaction equation

HRID 1169745 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5](I)=[CH:4][N:3]=1.CC1(C)C(C)(C)OB([C:19]2[S:20][CH:21]=[CH:22][CH:23]=2)O1>>[Cl:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[C:5]([C:19]2[S:20][CH:21]=[CH:22][CH:23]=2)=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 107036284,4,5,5-Tetramethyl-2-(thiophen-2-yl)-1,3,2-dioxaborolaneHCID 151888882-Chloro-5-iodo-4-methoxypyrimidine

Product 1

HCID 589856802-Chloro-4-methoxy-5-thiophen-2-yl-pyrimidineYield 54%

Procedure

Preparation according to procedure 3 with the use of 2-chloro-5-iodo-4-methoxy-pyrimidine and 4,4,5,5-tetramethyl-2-(2-thienyl)-1,3,2-dioxaborolane for 36 hrs at 95° C. In this way, a yield of 54% is obtained.

Workup

  1. customPreparation
  2. customIn this way, a yield of 54% is obtained

Sources & evidence

ORD record
ord-d8c003faca4b40b4b7143f54e57f06ee
Source dataset
uspto-grants-2010_11
Patent number
US07825128B2

Reaction notes

Loading…