反应详情

In the reaction of (RS)—N-(ethoxycarbonyl)-S-(4-{[4-{[(S)-1-(hydroxymethyl)-3-methylbutyl]amino}-5-(3-thienyl)pyrimidine-2-yl]amino}phenyl)-S-methyl-sulfoximide (135 mg, 0.26 mmol) with sodium ethylate (70 mg, 1.0 mmol) according to procedure 14, the desired product is obtained in 36% yield (42 mg) after chromatographic purification (silica gel, dichloromethane/methanol (9/1)).