反应详情

In the reaction of (RS)—S-{2-bromo-4-[(4-{[(R)-1-(hydroxymethyl)propyl]amino}-5-(2-thienyl)pyrimidine-2-yl)amino]phenyl}-N-(ethoxycarbonyl)-S-methyl-sulfoximide (130 mg, 0.23 mmol) with sodium ethylate (22 mg, 0.31 mmol) according to procedure 14, the desired product is obtained in 64% yield (73 mg) after chromatographic purification (silica gel, dichloromethane/ethanol (9/1)).