反应详情

In the reaction of (R)—N-(ethoxycarbonyl)-S-(4-{[4-{[(R)-2-hydroxy-1-methyl-ethyl]amino}-5-(2-thienyl)pyrimidine-2-yl]amino}phenyl)-S-cyclopropyl-sulfoximide with sodium ethylate according to procedure 14, the desired product is obtained in 82% yield after chromatographic purification (silica gel, dichloromethane/ethanol (0-10% ethanol)).