Acetic Anhydride → HCID 178474373、化合物

HRID 1169891ノート

反応式

HRID 1169891 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[C:15]([NH2:16])=[CH:14][NH:13][N:12]=2)=[O:10])=[CH:4][CH:3]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>N1C=CC=CC=1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[C:15]([NH:16][C:17](=[O:19])[CH3:18])=[CH:14][NH:13][N:12]=2)=[O:10])=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 178508056HCID 178508056、化合物

生成物 1

HCID 178474373HCID 178474373、化合物収率 46.2%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

4-Amino-1H-pyrazole-3-carboxylic acid (4-fluorophenyl)-amide (500 mg; 2.27 mmol) was dissolved in 5 ml of pyridine, treated with acetic anhydride (240 μl, 2.5 mmol) then stirred at room temperature overnight. The solvent was removed by evaporation then dichloromethane (20 ml) and 2M hydrochloric acid (20 ml) were added. The undissolved solid was collected by filtration, washed with more dichloromethane and water then dried under vacuum. The product was isolated as an off white solid (275 mg). (LC/MS: Rt 2.96, [M+H]+ 262.91).

後処理

  1. customThe solvent was removed by evaporation
  2. additiondichloromethane (20 ml) and 2M hydrochloric acid (20 ml) were added
  3. filtrationThe undissolved solid was collected by filtration
  4. washwashed with more dichloromethane and water
  5. customthen dried under vacuum

出典と根拠

ORDレコード
ord-6d973b6ef8ed42809bf6ee78f8754e37
出典データセット
uspto-grants-2010_11
特許番号
US07825140B2

反応ノート

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