Stannous Chloride → 2-Amino-5-fluorobenzonitrile

HRID 1169985Notes

Reaction equation

HRID 1169985 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]#[N:12])([O-])=O.Cl[Sn]Cl>Cl>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]#[N:12]

Participants

4

Reactant 2

HCID 24479Stannous ChlorideHCID 37564675-Fluoro-2-nitrobenzonitrile

Product 1

HCID 27377042-Amino-5-fluorobenzonitrile

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The title compound was synthesized from commercially available 2-nitro-5-fluorobenzenecarbonitrile via reduction with SnCl2 in concentrated HCl as previously described in the following reference which is herein incorporated by reference in its entirety for all purposes as if fully set forth herein: Hunziker, F. et al. Eur. J. Med. Chem., Chim. Ther. 1981, 16(5), 391. GC/MS m/z: 136.1 (M+, 100%), Rt 8.87 minutes.

Sources & evidence

ORD record
ord-01cbccf3425e409f9d5ffa2a1318af5c
Source dataset
uspto-grants-2010_11
Patent number
US07825132B2

Reaction notes

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