反应详情

To a solution of 5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzaldehyde (0.10 g, 0.24 mmol) in methanol (2.5 ml) was added sarcosine methyl ester hydrochloride salt (0.10 g, 0.72 mmol) followed by sodium triacetoxyborohydride (0.155 g, 0.73 mmol). After 15 hours the solvent was removed and the resultant solid taken up in methylene chloride. After washing with pH 7 phosphate buffer (0.05 M) and saturated aqueous sodium chloride the organic layer was dried over magnesium sulfate. After filtration and concentration the title compound was isolated by chromatography on silica gel (0.051 g).

1. customAfter 15 hours the solvent was removed
2. washAfter washing with pH 7 phosphate buffer (0.05 M) and saturated aqueous sodium chloride the organic layer
3. dry with materialwas dried over magnesium sulfate
4. filtrationAfter filtration and concentration the title compound
5. customwas isolated by chromatography on silica gel (0.051 g)