Morpholine → HCID 10727824, compound

HRID 1170003Notes

Reaction equation

HRID 1170003 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[C:8]1[N:13]=[C:12]([NH2:14])[C:11]([N+:15]([O-:17])=[O:16])=[CH:10][CH:9]=1>CC#N>[N:1]1([C:8]2[N:13]=[C:12]([NH2:14])[C:11]([N+:15]([O-:17])=[O:16])=[CH:10][CH:9]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 27240356-Chloro-3-nitropyridin-2-ylamine

Product 1

HCID 10727824HCID 10727824, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
70 °C

Procedure

Morpholine (4 equivalents) was added to a suspension of 6-chloro-3-nitropyridin-2-amine (1 equivalent) in CH3CN, and the reaction mixture was stirred at 70° C. for 5 hours. The solvent was evaporated under reduced pressure, and the residue was triturated with ether to afford the desired compound as a bright yellow powder. LC/MS m/z 225.0 (MH+), Rt 1.79 minutes.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was triturated with ether

Sources & evidence

ORD record
ord-6f06bab23aff4942b990179f511ece8a
Source dataset
uspto-grants-2010_11
Patent number
US07825132B2

Reaction notes

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