Triethylamine → 3-[2-(Methoxycarbonyl)acetylamino]pyridine-4-carboxylic acid

HRID 1170009Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1170009
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]([OH:10])=[O:9].Cl[C:12]([CH2:14][C:15]([O:17][CH3:18])=[O:16])=[O:13].C(N(CC)CC)C>CC(C)=O>[CH3:18][O:17][C:15]([CH2:14][C:12]([NH:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]([OH:10])=[O:9])=[O:13])=[O:16]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 123460Methyl malonyl chlorideHCID 4595313-Aminoisonicotinic acid

Produkt 1

HCID 129887813-[2-(Methoxycarbonyl)acetylamino]pyridine-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A solution of 3-aminopyridine-4-carboxylic acid (1.0 equivalent), methyl 2-(chlorocarbonyl)acetate (1.1 equivalents), and triethylamine (2.0 equivalents) in acetone was stirred overnight at room temperature. The solvent was removed in vacuo. The product was used without further purification. LC/MS m/z 239.2 (MH+), Rt 1.40 minutes.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customThe product was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-03cb5266c448490d83a64273a3285032
Quelldatensatz
uspto-grants-2010_11
Patentnummer
US07825132B2

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