HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-[2-(Methoxycarbonyl)acetylamino]pyridine-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl malonyl chloride | HCID 123460 | — |
| Reactant | 3-Aminoisonicotinic acid | HCID 459531 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 3-[2-(Methoxycarbonyl)acetylamino]pyridine-4-carboxylic acid | HCID 12988781 | — |
Reaction Steps
A solution of 3-aminopyridine-4-carboxylic acid (1.0 equivalent), methyl 2-(chlorocarbonyl)acetate (1.1 equivalents), and triethylamine (2.0 equivalents) in acetone was stirred overnight at room temperature. The solvent was removed in vacuo. The product was used without further purification. LC/MS m/z 239.2 (MH+), Rt 1.40 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07825132B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-03cb5266c448490d83a64273a3285032 |
| Source note | uspto-grants-2010_11 |