Methylamine → 1-(4-Benzylmorpholin-2-yl)-N-methylmethanamine

HRID 1170015Notes

Reaction equation

HRID 1170015 reaction equation
Cl[CH2:2][CH:3]1[O:8][CH2:7][CH2:6][N:5]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:4]1.[NH2:16][CH3:17]>CCO>[CH3:17][NH:16][CH2:2][CH:3]1[O:8][CH2:7][CH2:6][N:5]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:4]1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 28015624-Benzyl-2-(chloromethyl)morpholine

Product 1

HCID 513583991-(4-Benzylmorpholin-2-yl)-N-methylmethanamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
110 °C

Procedure

Commercially available 2-chloromethyl-4-benzyl morpholine was dissolved in an 8 M solution of NH2Me in EtOH and heated in a glass pressure vessel at 110° C. overnight. The solvent was removed in vacuo, and the compound was used in the next step without further purification. LC/MS m/z: 221.2 (MH+), Rt 0.55 minutes.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe compound was used in the next step without further purification

Sources & evidence

ORD record
ord-0efdc18641134e8f92b7623f3f715a2b
Source dataset
uspto-grants-2010_11
Patent number
US07825132B2

Reaction notes

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