4-Aminopyridine → N2-(5-Methyl-furan-2-ylmethyl)-N5-pyridin-4-yl-quinoline-2,5-diamine

HRID 1170111Notes

Reaction equation

I[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](Cl)=[N:7]2.[CH3:13][C:14]1[O:18][C:17]([CH2:19][NH2:20])=[CH:16][CH:15]=1.[NH2:21][C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1>>[CH3:13][C:14]1[O:18][C:17]([CH2:19][NH:20][C:6]2[CH:5]=[CH:4][C:3]3[C:2]([NH:21][C:22]4[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=4)=[CH:11][CH:10]=[CH:9][C:8]=3[N:7]=2)=[CH:16][CH:15]=1

Participants

Reactant 3

HCID 17274-Aminopyridine

HCID 27246835-Methyl-2-furylmethylamine

HCID 457894242-Chloro-5-iodoquinoline

Product 1

HCID 68436768N2-(5-Methyl-furan-2-ylmethyl)-N5-pyridin-4-yl-quinoline-2,5-diamine

Procedure

The title compound, MS: m/e=331.4 (M+H+), was prepared in accordance with the general method of example 1 from 5-iodo-2-chloroquinoline (CAS 455955-26-7), 5-methyl-2-furanmethanamine and 4-aminopyridine.

Sources & evidence

ORD record: ord-b5a207b1973b464ab43ed1d3a8613c49
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07825253B2

Reaction notes

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