4-Fluorobenzyl bromide → [5-(4-Fluoro-benzyloxy)-quinolin-2-yl]-(5-methyl-furan-2-ylmethyl)-amine

HRID 1170124Notes

Reaction equation

HRID 1170124 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](Cl)=[N:7]2.[CH3:13][C:14]1[O:18][C:17]([CH2:19][NH2:20])=[CH:16][CH:15]=1.[F:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26]Br)=[CH:24][CH:23]=1>>[F:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26][O:1][C:2]2[CH:11]=[CH:10][CH:9]=[C:8]3[C:3]=2[CH:4]=[CH:5][C:6]([NH:20][CH2:19][C:17]2[O:18][C:14]([CH3:13])=[CH:15][CH:16]=2)=[N:7]3)=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 680214-Fluorobenzyl bromideHCID 27246835-Methyl-2-furylmethylamineHCID 1354422212-chloroquinolin-5-ol

Product 1

HCID 68436831[5-(4-Fluoro-benzyloxy)-quinolin-2-yl]-(5-methyl-furan-2-ylmethyl)-amine

Procedure

The title compound, MS: m/e=363.3 (M+H+), was prepared in accordance with the general method of example 63 from 5-hydroxy-2-chloroquinoline (CAS 124467-35-2), 5-methyl-2-furanmethanamine and 4-fluoro-benzyl bromide.

Sources & evidence

ORD record
ord-51b285be26aa43a6af0ca4b53b0ce228
Source dataset
uspto-grants-2010_11
Patent number
US07825253B2

Reaction notes

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