2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-amine → N-{2-[(2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl)amino]quinolin-5-yl}-N'-(4-fluorophenyl)sulfamide

HRID 1170205Notes

Reaction equation

HRID 1170205 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8](Cl)=[N:9]2)([O-])=O.[NH2:15][C:16]1[C:24]2[O:23][C:22]([CH3:26])([CH3:25])[CH2:21][C:20]=2[CH:19]=[CH:18][CH:17]=1.[F:27][C:28]1[CH:33]=[CH:32][C:31]([NH:34][S:35](Cl)(=[O:37])=[O:36])=[CH:30][CH:29]=1>>[CH3:25][C:22]1([CH3:26])[CH2:21][C:20]2[CH:19]=[CH:18][CH:17]=[C:16]([NH:15][C:8]3[CH:7]=[CH:6][C:5]4[C:10](=[CH:11][CH:12]=[CH:13][C:4]=4[NH:1][S:35]([NH:34][C:31]4[CH:30]=[CH:29][C:28]([F:27])=[CH:33][CH:32]=4)(=[O:36])=[O:37])[N:9]=3)[C:24]=2[O:23]1

Participants

4

Reactant 3

HCID 916972,2-Dimethyl-2,3-dihydro-1-benzofuran-7-amineHCID 3192512-Chloro-5-nitroquinolineHCID 219665714-Fluoro-phenylsulfamoyl chloride

Product 1

HCID 68436653N-{2-[(2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl)amino]quinolin-5-yl}-N'-(4-fluorophenyl)sulfamide

Procedure

The title compound, MS: m/e=479.0 (M+H+), was prepared in accordance with the general method of example 58 from 5-nitro-2-chloroquinoline, 7-amino-2,3-dihydro-2,2-dimethylbenzofuran (CAS 68298-46-4) and 4-fluoro-phenylsulfamoyl chloride.

Sources & evidence

ORD record
ord-56d7e3b3032a4529a668dff19336b527
Source dataset
uspto-grants-2010_11
Patent number
US07825253B2

Reaction notes

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