反应详情

温度

120 °C

A mixture of piperazine (5 mmol) and 4-(7-fluoro-quinazolin-4-yl)-piperidine-1-carboxylic acid tert-butyl ester (1 mmol) in DMSO (1 mL) was stirred at 120° C. for 1 h. It was then diluted with water and extracted with DCM. The combined extracts were washed with water, brine, dried (anhydrous MgSO4), filtered and concentrated in vacuo to obtain 4-(7-piperazin-1-yl-quinazolin-4-yl)-piperidine-1-carboxylic acid tert-butyl ester.

1. extractionextracted with DCM
2. washThe combined extracts were washed with water, brine
3. dry with materialdried (anhydrous MgSO4)
4. filtrationfiltered
5. concentrationconcentrated in vacuo