Methylhydrazine → 2-[4-[4-(2-Chloro-pyridin-4-yl)-1-methyl-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline

Participants

Role	Name	HCID	Charge
Reactant	Methylhydrazine	HCID 6061	—
Reactant	2-{2-[4-(4-Pyridin-4-yl-2H-pyrazol-3-yl)-phenyl]-ethyl}-quinoline	HCID 11567005	—
Reactant	2-(2-Chloro-pyridin-4-yl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-ethanone	HCID 86249324	—
Product	2-[4-[4-(2-Chloro-pyridin-4-yl)-1-methyl-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline	HCID 11553672	—

Reaction Steps

Following the procedure for the preparation of 2-{2-[4-(4-Pyridin-4-yl-2H-pyrazol-3-yl)-phenyl]-ethyl}-quinoline but substituting methyl hydrazine and 2-(2-Chloro-pyridin-4-yl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-ethanone provided the title compound. 1H NMR (400 MHz, CDCl3) δ 8.19 (m, 2H), 8.07 (d, J=8.3 Hz, 1H), 7.83 (d, J=8.3 Hz, 1H), 7.74 (t, J=8.3 Hz, 1H), 7.67 (d, J=8.3 Hz, 1H), 7.58 (s, 1H), 7.55 (t, J=8.3 Hz, 1H), 7.36 (d, J=8.7 Hz, 2H), 7.20 (s, 1H), 7.03 (m, 3H), 5.40 (s, 2H) 3.95 (s, 3H); MS: (M+H m/z=427.0).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07825254B2
Source dataset	uspto-grants-2010_11
ORD ID	ord-253b382331524843bff8edc22e781845
Source note	uspto-grants-2010_11