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Hydrochloric Acid → 1-Phenyl-2-pyridin-2-ylethane-1,2-dione 2-oxime
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 1-Phenyl-2-(2-pyridinyl)ethanone | HCID 74179 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 1-Phenyl-2-pyridin-2-ylethane-1,2-dione 2-oxime | HCID 136406848 | — |
反応手順
A solution of 8.75 g (127 mmol) of sodium nitrite in water was added dropwise to a solution of 25 g (127 mmol) of 1-phenyl-2-pyridin-2-ylethanone in 250 ml of water/conc. hydrochloric acid (8:1) at room temperature. After 2 h, the solution was neutralized with sodium carbonate. The product crystallized out overnight to result in 25.3 g of 1-phenyl-2-pyridin-2-ylethane-1,2-dione 2-oxime.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07825264B2 |
| 出典データセット | uspto-grants-2010_11 |
| ORD ID | ord-8705773e83c54b16b80cb096800fd60a |
| 出典メモ | uspto-grants-2010_11 |