反应详情

A solution of 8.75 g (127 mmol) of sodium nitrite in water was added dropwise to a solution of 25 g (127 mmol) of 1-phenyl-2-pyridin-2-ylethanone in 250 ml of water/conc. hydrochloric acid (8:1) at room temperature. After 2 h, the solution was neutralized with sodium carbonate. The product crystallized out overnight to result in 25.3 g of 1-phenyl-2-pyridin-2-ylethane-1,2-dione 2-oxime.

1. customat room temperature
2. customThe product crystallized out overnight
3. customto result in 25.3 g of 1-phenyl-2-pyridin-2-ylethane-1,2-dione 2-oxime