Sodium Hydroxide → HCID 178464152, compound

HRID 1170422Notes

Reaction equation

HRID 1170422 reaction equation
Cl.[CH2:2]([N:4]([CH2:10][CH3:11])[C@H:5]1[CH2:8][C@@H:7]([OH:9])[CH2:6]1)[CH3:3].[OH-].[Na+]>CO>[CH2:2]([N:4]([CH2:10][CH3:11])[C@H:5]1[CH2:8][C@@H:7]([OH:9])[CH2:6]1)[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178464154HCID 178464154, compound

Product 1

HCID 178464152HCID 178464152, compoundYield 89.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Cis-1-diethylamino-3-hydroxycyclobutane hydrochloride (100 mg, 0.557 mmol) was dissolved in methanol (3.0 ml), and thereto was added 1N aqueous sodium hydroxide solution (0.560 mL, 0.560 mmol). The mixture was evaporated, and thereto were added ethyl acetate and tetrahydrofuran, and the mixture was dried over sodium sulfate, and filtered. The filtrate was evaporated to give the titled compound (71.7 mg).

Workup

  1. customThe mixture was evaporated
  2. additionwere added ethyl acetate and tetrahydrofuran
  3. dry with materialthe mixture was dried over sodium sulfate
  4. filtrationfiltered
  5. customThe filtrate was evaporated

Sources & evidence

ORD record
ord-ae638c4064f74409b76e79ced386a16a
Source dataset
uspto-grants-2010_11
Patent number
US07825155B2

Reaction notes

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