反应详情

温度

100 °C

To a solution of the compound of Example 1-4 (400.0 mg, 0.69 mmol) in acetic acid (2.5 mL) was added 47% hydrobromic acid (7.5 mL), and the mixture was stirred at 100° C. for 2 hours. The reaction solution was concentrated, and then recrystallized (methanol-diethyl ether) to give the titled compound (420.5 mg, 98%).

1. concentrationThe reaction solution was concentrated
2. customrecrystallized (methanol-diethyl ether)