Methylamine → HCID 178464136, compound

HRID 1170437Notes

Reaction equation

HRID 1170437 reaction equation
Br.[Cl:2][C:3]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:4]=1[C:10]1([OH:37])[C:18]2[C:13](=[CH:14][C:15]([C:23](O)=[O:24])=[CH:16][C:17]=2[C:19]([F:22])([F:21])[F:20])[N:12]([CH2:26][C@H:27]2[CH2:30][C@H:29]([N:31]([CH2:34][CH3:35])[CH2:32][CH3:33])[CH2:28]2)[C:11]1=[O:36].[CH3:38][NH2:39]>>[ClH:2].[CH3:38][NH:39][C:23]([C:15]1[CH:14]=[C:13]2[C:18]([C:10]([C:4]3[CH:5]=[CH:6][C:7]([Cl:9])=[CH:8][C:3]=3[Cl:2])([OH:37])[C:11](=[O:36])[N:12]2[CH2:26][C@H:27]2[CH2:30][C@H:29]([N:31]([CH2:34][CH3:35])[CH2:32][CH3:33])[CH2:28]2)=[C:17]([C:19]([F:20])([F:22])[F:21])[CH:16]=1)=[O:24]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 178419562HCID 178419562, compound

Product 1

HCID 178464136HCID 178464136, compoundYield 40%

Procedure

The compound of Example 8 (200 mg, 0.32 mmol) and excess amount of methylamine were reacted in a similar manner to Example 9 to give the titled compound (75.0 mg, 40%).

Sources & evidence

ORD record
ord-a169e040e51840b5b2933031394c4c35
Source dataset
uspto-grants-2010_11
Patent number
US07825155B2

Reaction notes

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