Hydrochloric Acid → HCID 178464133, compound

HRID 1170442Notes

Reaction equation

HRID 1170442 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1([OH:38])[C:17]2[C:12](=[CH:13][C:14]([C:22]3[O:23][CH:24]=[CH:25][N:26]=3)=[CH:15][C:16]=2[C:18]([F:21])([F:20])[F:19])[N:11]([CH2:27][C@H:28]2[CH2:31][C@H:30]([N:32]([CH2:35][CH3:36])[CH2:33][CH3:34])[CH2:29]2)[C:10]1=[O:37].Cl>C(#N)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1([OH:38])[C:17]2[C:12](=[CH:13][C:14]([C:22]3[O:23][CH:24]=[CH:25][N:26]=3)=[CH:15][C:16]=2[C:18]([F:19])([F:20])[F:21])[N:11]([CH2:27][C@H:28]2[CH2:29][C@H:30]([N:32]([CH2:33][CH3:34])[CH2:35][CH3:36])[CH2:31]2)[C:10]1=[O:37]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178464132HCID 178464132, compound

Product 1

HCID 178464133HCID 178464133, compoundYield 188.9%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of the compound of Example 14-3 (80 mg, 0.140 mmol) in acetonitrile (1 mL) was added 4N hydrochloric acid (0.1 mL), and the mixture was concentrated in vacuo and dried to give the titled compound (80 mg, quant.).

Workup

  1. concentrationthe mixture was concentrated in vacuo
  2. customdried

Sources & evidence

ORD record
ord-f025825f6f4f4d66aac312950252652c
Source dataset
uspto-grants-2010_11
Patent number
US07825155B2

Reaction notes

Loading…