反应详情

温度

100 °C

To a solution of the compound of Example 1-3 (40 mg, 0.076 mmol) in toluene (2 mL) were added triethylamine hydrochloride (10.8 mg, 0.076 mmol) and sodium azide (10.0 mg, 0.154 mmol) under nitrogen, and the mixture was stirred at 100° C. for 5 hours. The reaction solution was concentrated in vacuo and the residue was purified by preparative liquid chromatography to give the titled compound (15 mg).

1. concentrationThe reaction solution was concentrated in vacuo
2. customthe residue was purified by preparative liquid chromatography