反应详情

A solution of 1,1-dimethylethyl 2-chloro-α-[(dimethylamino)methylene]-β-oxo-benzenepropanoate (25.5 mg, 0.082 mmol) in 1 mL of toluene was treated with 4-iodoaniline (17.9 mg, 0.082 mmol) added as a solid in one portion. After stirring overnight, the reaction was concentrated in vacuo and the residue was adsorbed onto silica gel and added to 19.5 cm of flash silica in a 2 cm dia. column. Elution with 5:1 hexanes/EtOAc gave the title compound as a solid.

1. additionadded as a solid in one portion
2. concentrationthe reaction was concentrated in vacuo
3. additionadded to 19.5 cm of flash silica in a 2 cm dia
4. washElution with 5:1 hexanes/EtOAc