反应详情

2,2-Dimethyl-3-(N-CBz-D-valyloxy)-propionic acid chloromethyl ester (2.4 g, 6 mmole) was dissolved in acetonitrile (30 ml). Sodium iodide (1.26 g, 8.4 mmole) was added to the solution. After reaction at 70° C. for 2 hr, the reaction mixture was filtered and the residue was dissolved in methylene chloride (20 ml) and refiltered. The solution was dried and gave the titled product. 2.68 g.

1. customAfter reaction at 70° C. for 2 hr
2. filtrationthe reaction mixture was filtered
3. dissolutionthe residue was dissolved in methylene chloride (20 ml)
4. customThe solution was dried