反应详情

To a solution of 2-amino-2-methyl-1-(N-benzyloxycarbonyl-L-valyloxy)-propane (2.9 g, 9 mmole) and pyridine (2 ml) in dichloromethane (50 ml) was added chloromethyl chloroformate (1.55 g, 12 mmole) and the mixture was stirred for 3 hours at room temperature. The mixture was evaporated under reduced pressure and ethyl acetate was added. The organic phase was washed with water, dried with sodium sulfate and evaporated under reduced pressure. The product was isolated by silica gel column chromatography with hexane/ethyl acetate. Yield: 1.1 g=29%.

1. customThe mixture was evaporated under reduced pressure and ethyl acetate
2. additionwas added
3. washThe organic phase was washed with water
4. dry with materialdried with sodium sulfate
5. customevaporated under reduced pressure
6. customThe product was isolated by silica gel column chromatography with hexane/ethyl acetate