反应详情

To a solution of 2-(N-(chloromethoxycarbonyl)-amino)-2-methyl-1-(N-benzyloxycarbonyl-L-valyloxy)propane (1.05 g, 2.53 mmole) in dry acetone (20 ml) was added sodium iodide (1.8 g, 12 mmole) and the mixture was stirred for 36 hours at room temperature. The mixture was evaporated under reduced pressure and ethyl acetate and water were added. The organic phase was washed with 10% sodium thiosulfate solution and water. The organic phase was dried with sodium sulfate and evaporated under reduced pressure. Yield: 1.04 g=81%.

1. customThe mixture was evaporated under reduced pressure and ethyl acetate and water
2. additionwere added
3. washThe organic phase was washed with 10% sodium thiosulfate solution and water
4. dry with materialThe organic phase was dried with sodium sulfate
5. customevaporated under reduced pressure