Sodium Iodide → HCID 18400042, compound

HRID 1170692Notes

Reaction equation

HRID 1170692 reaction equation
[CH3:1][O:2][C:3]1[CH:21]=[CH:20][C:6]([CH2:7][O:8][C:9]2[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16]Cl)=[O:14])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[I-:22].[Na+]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:21]=[CH:20][C:6]([CH2:7][O:8][C:9]2[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][I:22])=[O:14])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 22035697HCID 22035697, compound

Product 1

HCID 18400042HCID 18400042, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of chloromethyl 4-(4-methoxybenzyloxy)benzoate (0.77 g, 2.5 mmole) in 15 ml dry acetone was added sodium iodide (1.87 g, 12.5 mmole) and the mixture was stirred overnight at room temperature. The mixture was evaporated under reduced pressure and extracted with ethyl acetate/water. The organic phase was washed with a 5% sodium thiosulfate solution, dried with sodium sulfate and evaporated under reduced pressure. Yield 0.86 g=86%

Workup

  1. customThe mixture was evaporated under reduced pressure
  2. extractionextracted with ethyl acetate/water
  3. washThe organic phase was washed with a 5% sodium thiosulfate solution
  4. dry with materialdried with sodium sulfate
  5. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-0e83f2d75aaa4a5cbd831091812e3581
Source dataset
uspto-grants-2010_11
Patent number
US07825238B2

Reaction notes

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