反应详情

PPh3 (3.08 g, 11.8 mmol) and CBr4 (2.93 g, 8.82 mmol) were added to a solution of 37 (1.00 g, 5.88 mmol) in DCM (20 mL) under nitrogen and stirred at room temperature for 1 h. The reaction mixture was filtered, concentrated and chromatographed to isolate the 49 as a colorless solid (0.85 g, 62% yield).

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated
3. customchromatographed