Hydrochloric Acid → HCID 59552399, compound

HRID 1170783Notes

Reaction equation

HRID 1170783 reaction equation
[N:1]([CH2:4][C:5]([NH:7][C@H:8]([CH2:14][S:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([O:23]C2CCCCO2)[CH:18]=1)[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[O:6])=[N+:2]=[N-:3].Cl>CO>[N:1]([CH2:4][C:5]([NH:7][C@H:8]([CH2:14][S:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([OH:23])[CH:18]=1)[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[O:6])=[N+:2]=[N-:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59552494HCID 59552494, compound

Product 1

HCID 59552399HCID 59552399, compoundYield 92.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a 250 mL round bottom flask containing 132 (6.5 g, 15.4 mmol) in MeOH (150 mL) at RT, was added Cone. HCl (1 mL) and stirred for 2.5 h. The reaction was concentrated on silica and purified over silica gel using EtOAc:Hexanes (1:1) as an eluent to afford 133 (4.8 g, 92%) as a colorless oil.

Workup

  1. additionwas added Cone
  2. concentrationThe reaction was concentrated on silica
  3. custompurified over silica gel

Sources & evidence

ORD record
ord-2d45d8b046e045d4a7c2cd7fbb2b1474
Source dataset
uspto-grants-2010_11
Patent number
US07829063B2

Reaction notes

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