Oxalic acid dihydrate → HCID 11620876, compound

HRID 1170852Notes

Reaction equation

HRID 1170852 reaction equation
[C:1]([C:4]([OH:6])=[O:5])([OH:3])=[O:2].O.O.[Cl:9][C:10]1[CH:11]=[C:12]([N:17]2[C:25]3[CH2:24][CH2:23][CH2:22][CH:21]([CH2:26][CH2:27][N:28]4[CH2:33][CH2:32][CH:31]([C:34]5[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=5)[CH2:30][CH2:29]4)[C:20]=3[CH:19]=[N:18]2)[CH:13]=[CH:14][C:15]=1[Cl:16]>CC(C)=O>[C:4]([OH:6])(=[O:5])[C:1]([OH:3])=[O:2].[Cl:9][C:10]1[CH:11]=[C:12]([N:17]2[C:25]3[CH2:24][CH2:23][CH2:22][CH:21]([CH2:26][CH2:27][N:28]4[CH2:29][CH2:30][CH:31]([C:34]5[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=5)[CH2:32][CH2:33]4)[C:20]=3[CH:19]=[N:18]2)[CH:13]=[CH:14][C:15]=1[Cl:16]

Participants

4

Reactant 2

HCID 61373Oxalic acid dihydrateHCID 11554272HCID 11554272, compound

Product 1

HCID 11620876HCID 11620876, compoundYield 74.2%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

HO2CCO2H.2H2O (40 mg, 0.32 mmol) is added to a solution of 1-(3,4-dichlorophenyl)-4,5,6,7-tetrahydro-4-(2-(4-phenylpiperidin-1-yl)ethyl)-1 H-indazole (140 mg, 0.31 mmol) in 4 mL of acetone, giving 1-(3,4-dichlorophenyl)-4,5,6,7-tetrahydro-4-(2-(4-phenylpiperidin-1-yl)ethyl)-1H-indazole oxalate (125 mg, 0.23 mmol, 74%, white solid).

Sources & evidence

ORD record
ord-f9d5bc6acd8143f98861f5ef5a8912ed
Source dataset
uspto-grants-2010_11
Patent number
US07829559B2

Reaction notes

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