Hydroxyamine hydrochloride → HCID 178487252, compound

HRID 1170881Notes

Reaction equation

HRID 1170881 reaction equation
[CH3:1][O:2][C:3]1[CH:19]=[CH:18][C:17]2[C:8]3[CH:9]=[N:10][C:11]4[C:16]([C:7]=3[C:6](=O)[C:5]=2[CH:4]=1)=[CH:15][CH:14]=[CH:13][CH:12]=4.[NH2:21][OH:22].Cl>C(OC(O)C)C>[CH3:1][O:2][C:3]1[CH:19]=[CH:18][C:17]2[C:8]3[CH:9]=[N:10][C:11]4[C:16]([C:7]=3[C:6](=[N:21][OH:22])[C:5]=2[CH:4]=1)=[CH:15][CH:14]=[CH:13][CH:12]=4

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 446043839-Methoxy-11H-indeno[1,2-c]quinolin-11-one

Product 1

HCID 178487252HCID 178487252, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 101298981-EthoxyethanolSolvent

Procedure

To a suspension of compound 5d (0.26 g, 1 mmol) in ethoxyethanol (30 mL) was added NH2OH·HCl (0.20 g, 3 mmol). The reaction mixture was heated with stirring under microwave irradiation (100 W) for 30 min (by TLC monitoring), followed by concentration in vacuo. A solid thus obtained was recrystallized from MeOH to give the title compound 6a (0.20 g, 73% yield).

Workup

  1. temperatureThe reaction mixture was heated
  2. concentrationfollowed by concentration in vacuo
  3. customA solid thus obtained
  4. customwas recrystallized from MeOH

Sources & evidence

ORD record
ord-d2c6e95da4ca4d09aa826a148fc6d428
Source dataset
uspto-grants-2010_11
Patent number
US07829567B2

Reaction notes

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